Antinaus 50

Generic Name: promethazine (injection) (pro METH a zeen)
Brand Names: Adgan, Anergan 50, Antinaus 50, Pentazine, Phenergan

Promethazine is in a group of drugs called phenothiazines (feen-oh-THYE-oh-zeens).

Promethazine is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures.

Promethazine injection is usually given when a person cannot take the medication orally (by mouth).

Promethazine injection may also be used for purposes other than those listed in this medication guide.

If you have certain conditions, you may need a dose adjustment or special tests to safely receive this medication. Before you receive promethazine injection, tell your doctor if you are allergic to any drugs, or if you have:

• asthma, sleep apnea, or other breathing problems;

• epilepsy or other seizure disorder;

• a weak immune system (bone marrow depression);

• glaucoma;

• enlarged prostate or problems with urination;

• stomach ulcer or obstruction;

• heart disease or high blood pressure;

• liver disease;

• adrenal gland tumor (pheochromocytoma);

• low levels of calcium in your blood (hypocalcemia); or

• if you have ever had a serious side effect while using promethazine or any other phenothiazine.

Promethazine injection is given as an injection deep into a muscle. You will receive this injection in a clinic or hospital setting. This medication is usually given every 2 to 4 hours depending on the condition it is used for.

Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by mouth.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you have recently received promethazine injection.

Since promethazine injection is given by a healthcare professional, it is not likely that you will miss a dose.

Overdose symptoms may include slow or shallow breathing, extreme drowsiness or weakness, feeling light-headed, or fainting.

• twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

• tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;

• feeling restless, jittery, or agitated;

• slow, shallow breathing, feeling like you might pass out;

• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

• pain, burning, severe irritation, muscle weakness, or skin changes where the injection was given;

• confusion, hallucinations, hysteria, seizure (black-out or convulsions);

• fast or slow heartbeats;

• fever, chills, body aches, flu symptoms;

• urinating less than usual or not at all;

• easy bruising or bleeding, unusual weakness; or

• jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• drowsiness, dizziness, tired feeling;

• ringing in your ears;

• problems with balance or coordination;

• blurred vision;

• feeling nervous or shaky;

• sleep problems (insomnia);

• skin rash or itching;

• dry mouth, stuffy nose;

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Also tell your doctor if you are using any of the following medicines:

• lithium (Eskalith, Lithobid);

• atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

• blood pressure medication such as guanadrel (Hylorel), guanethidine (Ismelin), propranolol (Inderal), and others;

• a blood thinner such as warfarin (Coumadin);

• bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

• bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others;

• an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or

• medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma); or

• medicine to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine).

This list is not complete and there are many other medicines that can interact with promethazine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

• Your doctor or pharmacist has information about promethazine injection.

• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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